The 2025 Digital Health Most Wired (DHMW) Interoperability & Population Health segment report examines how healthcare organizations exchange data across networks, turn shared information into coordinated workflows, and improve population health outcomes through advanced adoption of person-centric digital health ecosystems. This section measures not only technical connection, but also the strategic, operational and cultural maturity required to make interoperability actionable, from data governance and data sharing frameworks, to affiliate EHR hosting, population health analytics, predictive modeling, and digital communications.